We used high-quality postmortem human brain samples to examine oxidative stress, cell signaling, vascular lesion, and AD hallmarks. We use cutting-edge intravital imaging techniques to investigate the function and interaction of brain cells (neuron and astrocytes) and cerebrovasculatures. We develop our own protocol to generate a novel mixed AD and vascular pathology at a single capillary level. This is a model of vascular oxidative stress that shows impair of neurovascular coupling function and degeneration of perivascular cells. We investigate molecular mechanism and cell signaling that involve in both degeneration and regeneration of these cells. Furthermore, we use electrophysiology techniques to measure basal synaptic transmission and synaptic plasticity as well as animal behavior to characterize our animal models.

November 3rd, 2023 @ Healthy Kentucky Research Building

October 14th, 2023 @Bi-Water Farm & Greenhouse in Georgetown, KY
Let’s grab some snacks, drinks, and grilled hot dogs then celebrate and joy together with Norris Lab